Pharmaceutics-1 available questions: [CoU-2021, CoU-2020, CoU-2017, CoU-2019]
Pharmaceutics-2 available questions: [CoU-2020]
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[CoU-2021] Pharmaceutics-1
Define pharmaceutical excipient. Why is it necessary?
What is antioxidant? Classify it with example.
Why preservatives are important in pharmaceutical formulation?
Write on: (1) humectants (iii) antifoaming agent.
What is syrup? Give its advantages and disadvantages.
Illustrate complexation and salt formation of a drug
Define: (1) elixir (ii) linctus (iii) collodions (iv) lotion.
Demonstrate the theory of sedimentation of drug particle in a liquid preparation.
Discuss the antiparticle forces of drug in suspension.
Write note on: (i) flocculation (ii) coalescence.
What is zeta potential? Mention its importance.
What do you mean by solubility? Write down the factors affecting solubility.
What is cosolvent? What are the roles of cosolvent?
What is buffer? Write down the significance of buffer in biological systems.
Classify emulgents with example.
Illustrate the hydrophilic-lipophilic balance value of surfactants.
Briefly describe the assessment procedure of emulsion shelf-life.
What do you mean by semisolid dosage form? Differentiate among ointment, paste and cream.
Discuss the factors that affect the absorption of drug through skin.
Classify ointment base with example.
Discuss about the structure of skin.
What is penetration enhancer? Describe about various penetration enhancer.
Illustrate the evaluation methods of ointments.
Write about any three topics from the following:
a) Colouring agent.
b) Emulsion instability.
e) Effect of plon solubility profile of a drug.
d) Controlled flocculation.
e) Micellization.
[CoU-2020] Pharmaceutics-1
Define pharmaceutical excipient . Write the significance of it in pharmacy.
What is antioxidant? Classify it with example.
Why are preservatives called stabilizer?
Write on i ) co - solvent ii ) humectants ii ) anti foaming agent
What is syrup? Differentiate between O/W and W/O emulsions.
Illustrate complexation and salt formation of a drug.
Write on : i ) elixir ii ) liniments iii ) colloids iv ) lotion
Describe the effects of PH solubility of drug.
Classify various types of solutions.
Define preformulation. Why preformulation is needed in dosage form development?
Define zeta potential and adsorption.
Differentiate between flocculated and non-flocculated suspension.
Define emulsifying agents. Give the classification of emulsifying agents with example.
Describe the precipitation method of suspension formulation. Write the ideal properties of suspending agents.
Classify emulsifying agents with example.
Illustrate the hydrophilic and lipophillic balance of surfactants. Briefly state the assessment procedure of emulsion shelf-life.
Discuss various methods of emulsion formation.
What do you mean by HLB? Write on the methods of calculating HLB value of emulsifying agents.
Mention the functional and non-functional purposes of coating polymers and functions of diluents in pharmaceutical dosage form.
How can you classify suppositories?
Mention the advantages and disadvantages of suppositories.
Give the ideal properties of a suppository base.
Discuss the factors that affect drug absorption from colon.
Derive an equation that shows the relationship between ionized and unionized drug concentration with pH for an acidic drug.
Narrate the factors that affect skin penetration of semisolid drug.
Illustrate the quality control process of semi-solid drug.
[CoU-2019] Pharmaceutics-1
Define pharmaceutical excipient. Classify it with example.
What is antioxidant? How does an antioxidant acts?
What do you mean by:
i) foarming agent ii) humectants iii) air displacement agents
What is syrup? What are its advantages and disadvantages.
Illustrate complexation and salt formation of drug for increasing solubility.
Write down the various types of solutions.
What is preformulation? Evaluate the importance of preformulation.
Discuss on the bulk characterization of drug
Write on: (i) eta potential (i) flocculation.
What is semi-solid drug? Compare and contrast between ointment and cream.
Narrate the physiology of skin with figure.
Describe how the quality of a semisolid drug is assessed.
What are suppositories? Evaluate their rational use compared with other form of drug.
Describe the evaluation process of suppositories.
Narrate the factors affecting drug absorption from colon.
Elaborate on the desired features of an emulsion. State various advantages and disadvantages of emulsion.
Describe various QC tests and stress tests for emulsion.
Write a short note on additives used in preparation of emulsion.
Last five patient conditions or attributes which would cause you to use a rectal route of administration for a drug rather than another type of dosage form. Explain the differences between suspension and emulsion.
Mention in detail about stability problems encountered by suspension.
Explain about flocculated and deflocculated suspension.
Write short note on
i) Polymorphism ii) Partion coefficient iii) Bulk density iv) Hygroscopicity
Discuss the protocols followed in the preformulation studies.
Briefly write about handing of prescription. Write about imperial system of weights and measures.
[CoU-2017] Pharmaceutics-I
What are excipients? Why they are important in formulation?
How does a disintegrant cause double DT of tablet?
Define preservative. Which factors should be considered in choice of a preservative?
How does antioxidant activity can be improved?
What is compounding? Which factors are vital in compounding?
Write the qualities of good containers and closures.
State the mechanism of filtration.
What are the advantages and disadvantages of plastic containers?
Which information you can obtain from preformulation study?
"Prodrug overcome formulation problem without compromising bioavailability"-Justify the statement with example.
Why common ion effect is important in dissolution and absorption?
How does solution stability tested?
State the process of determining pH of aqueous solution.
What is dielectric constant? Why it is important in solubility?
Which factors should be considered in choice of solubilizer?
Differentiate among solution, colloid and suspension.
Which methods a pharmacist should apply to overcome common filling problem?
Give the theory of solution made with polar solvent and ionic solute.
What are the merits of liquid dosage forms?
Define with example- i) Antifoaming agent ii) Co-solvents
What are the limitations of chemical modification used to improve solubility of drug?
Dictate the formulation and advantages of water removable bases
Which factors affect percutaneous absorption of drug Briefly describe the packaging of semisolids.
Why particle size is important in suspension preparation
Explain the optical phenomena of colloidal dispersion?
Distinguish between flocculated and deflocculated suspension
What are electrophoresis and electroosmosis ?
Define suppository. Classify different type of suppositories.
Illustrate different formulation method of suppositories.
Write the factors affecting the drug absorption from colon.
[CoU-2020] Pharmaceutics-2
Discuss the reasons for granulation. Give a flow chart for manufacturing of tablets by wet and dry granulation.
For which kind of ingredients direct compression method is preferable?
Write down the advantages of solid dosage form in comparison to liquid dosage form.
Classify tablets with example.
What are caplets? Show the difference between tablet and pill.
What are the functions of excipients in tablets?
Give two examples of disintegrants, granulating agents, lubricants and coloring agents with their percentages used in tablet formulation.
Why are disintegrating agents added in two portions?
Give short notes on capping, lamination, cracking and sticking.
Why is friability test needed for physical evaluation a tablet?
Write the properties of an ideal granulating agent.
Show the difference between dry granulation and wet granulation methods of tablet formation.
What is compaction and compression of powder in tablet formation?
How can you evaluate the weight variation and drug contents of tablets?
Mention the factors which affect the strength of tablet.
How does particle size affect the flow rate of powder during compression?
Define tablet coating. What are the purposes of tablet coating?
What are the key factors to be considered during film coating process?
What are the problems of organic and aqueous film coating?
Why film coating is preferable than sugar coating?
Define gelatin as a major component of the capsule. Mention the source and properties of gelatin.
Discuss the formulation factors affecting the stability of soft gelatin capsule.
For a capsule formulation, the theoretical fill weight is 350 mg and the tapped bulk density is 0.50 gm/nl. How can you determine the right capsule size for this formulation?
Mention the limitation of filling materials in capsule formulation.
Briefly discuss the methods of preparation of soft gelatin capsule.
Write the difference between hard and soft gelatin capsule.
Explain about the bloom strength, plasticizer and opacifiers.
How can you differentiate between type-A gelatin and type- B gelatin.
Define microcapsules and microspheres. Write the reasons for microcapsulation.
How can you manufacture a microencapsulated product by air suspension method!
Enumerate the release mechanisms of microcapsulated product.
Give a list of microcapsulated drugs.
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