[CoU-2021] Medicinal Chemistry-II
Define lead compound and its importance in drug discovery.
"The side effect of a drug is useful for the development of a new drug"- explain with example.
What is pro drug? How the concept of prodrug be used in drug design?
Explain how serendipity and the prepared mind can be a source of a lead compound?
Define QSAR. Mention the rationale for QSAR study.
Hydrophobicity plays an important role in QSAR study- explain with example.
Write down the Hansch equation with it's significance.
"Therapeutic effects and side effects are fully subjective and depends on the purpose of use"- Explain
What do you mean by SAR? How SAR is related with the pharmacokinetic of the drug?
Define the following term.
(1) Pharmacon
(ii) Pharmaca and
(ii) Pharmacophore
Define combinational chemistry. Discuss the role of combinational synthesis in drug discovery.
Write down the stages involved in solid phase peptide synthesis.
Differentiate between solid phase and solution combinational synthesis.
What is meant by detoxification of drugs? Mention the consequences of biotransformation of Drug.
Explain the hydrolysis and glutathione conjugation steps for drug metabolism.
Discuss in brief about pharmaceutical and pharmacological strategies to manage rapid drug metabolism.
Give four examples of alkylating agents Describe the mechanism of action ofalkylatingagents.
What are the characteristics of cancer cells.
Show the mechanism of action of methotrexate and 5-FU.
Briefly describe the chemistry and SAR of cephalosporin antibiotics
Describe the mechanism of action of ciprofloxacin.
How penicillin is biosynthesized from its precursors?
Mention the chemistry of local anaesthetics. Describe a method of procaine synthesis.
Explain how diaminopyrimidines work as an antimalarial drug.
Classify local anaesthetics on the basis of chemical structure and give example of each class.
Mention the therapeutic purposes of diethyl stilbesterol.
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