Medicinal Chemistry Question Database

Available questions [CoU-2022, CoU-2021]

[CoU-2022] Medicinal Chemistry-II

 

Define drug design and drug development.

 

What are the primary goals of drug design?

 

The side effects of drugs are useful for the development of new drug; - Justify.

 

Explain that- Pharmaceutical design is prerequisite for new drug development.

 

What do you know about pharmaca, pharmacon, metabolic blocker and produg?

 

Illustrate the requirements for identification of lead compounds.

 

Write the role of biotechnology in drug design.

 

What is bioisosterism and homologation?

 

What is Combinatorial chemistry? Why Combinatorial chemistry is preferable to search lead compare with conventional?

 

What is solid phase peptide synthesis (SPPS)? Give the application of solid phase peptide synthesis (SPPS) in drug discovery processes.

 

What is Dendrimer? Write the properties and applications of Dendrimer in liquid phase combinatorial synthesis.

 

Mention the applications of Combinatorial chemistry.

 

What is biotransformation? Discuss the phase-I and phase-II reaction of drug biotransformation.

 

Enumerate the factors which affect drug metabolism.

 

Explain with examples that the metabolites play an important role in the development of new drug.

 

What is cancer chemotherapy? State the pathogenesis of cancer.

 

How does alkylating agent act as anticancer drug? Describe the SAR of nitrogen mustard.

 

Mention the therapeutic uses of methotrexate and pyrimidine analogues.

 

What is insulin? Give the chemistry and mechanism of action of insulin.

 

Demonstrate the chemistry, SAR and mechanism of action of Sulfonyl urea.

 

What is insulin resistance? How can you manage hypoglycemic shock?

 

Write the chemistry, SAR and mechanism of action of local anesthetics.

 

Enumerate the criteria of ideal local anaesthetics.

 

What is Non-steroidal Oestrogens? Write the synthesis of stilbesterol with its indications?

 

Give the pharmacological actions, therapeutic uses and adverse effects of cocaine.

 

What is schizophrenia? Mention the behaviors that are early warning signs of schizophrenia?

 

How benzodiazepines act as an anti-anxiety drug?

[CoU-2021] Medicinal Chemistry-II

Define lead compound and its importance in drug discovery.

"The side effect of a drug is useful for the development of a new drug"- explain with example.

What is pro drug? How the concept of prodrug be used in drug design?

Explain how serendipity and the prepared mind can be a source of a lead compound?

Define QSAR. Mention the rationale for QSAR study.

Hydrophobicity plays an important role in QSAR study- explain with example.

Write down the Hansch equation with it's significance.

"Therapeutic effects and side effects are fully subjective and depends on the purpose of use"- Explain

What do you mean by SAR? How SAR is related with the pharmacokinetic of the drug?

Define the following term.

(1) Pharmacon

(ii) Pharmaca and

(ii) Pharmacophore

Define combinational chemistry. Discuss the role of combinational synthesis in drug discovery.

Write down the stages involved in solid phase peptide synthesis.

Differentiate between solid phase and solution combinational synthesis.

What is meant by detoxification of drugs? Mention the consequences of biotransformation of Drug.

Explain the hydrolysis and glutathione conjugation steps for drug metabolism.

Discuss in brief about pharmaceutical and pharmacological strategies to manage rapid drug metabolism.

Give four examples of alkylating agents Describe the mechanism of action ofalkylatingagents.

What are the characteristics of cancer cells.

Show the mechanism of action of methotrexate and 5-FU.

Briefly describe the chemistry and SAR of cephalosporin antibiotics

Describe the mechanism of action of ciprofloxacin.

How penicillin is biosynthesized from its precursors?

Mention the chemistry of local anaesthetics. Describe a method of procaine synthesis.

Explain how diaminopyrimidines work as an antimalarial drug.

Classify local anaesthetics on the basis of chemical structure and give example of each class.

Mention the therapeutic purposes of diethyl stilbesterol.