Pharmaceutical Analysis-1 available questions for Khulna University: [2019-2020, 2017-18, 2015-16]
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Khulna University
Session: 2019-2020
Pharmaceutical Analysis-1
Draw and describe the titration curve for weak base with weak acid.
Describe the mechanism with example how an indicator works.
What is a pH scale?
Differentiate between acid and base.
The drug ephedrine is a peudoalkaloid. Why and how can you titrate it using non-aqueous titration?
"Nonaqueous titration is very much useful in pharmaceutical quality control"- why?
Classify non-aqueous solvents with examples.
What are the disadvantages of nonaqueous titration?
Classify ligands with examples according to the number of sites of attachment to the metal ion.
Define and describe the importance of masking agent in complexometric titration.
Why EDTA is the most useful titrant in complexometric titration?
How can you titrate ephedrine using non-aqueous titration?
What do you mean by back titration? Explain with example.
How can you increase the acidity of an acid or the basicity of a base?
Why multidentate ligands are more commonly used than unidentate?
Write down the principle of UV spectroscopy for drug molecule identification.
Mention the importance of different spectroscopic methods used in pharmaceutical analysis.
"Energy required for transition depend on compounds bonding"- Justify the statement.
Define electro-magnetic radiation (EMR). Write down the general properties of EMP.
Briefly describe the beer-lambert law.
Calculate the energy associated with a radiation having wavelength 5000A° in kcal per mole.
"UV spectroscopy is based on the principle of electronic transition"-explain.
What is forbidden transition?
Draw and describe the instrumentation of UV spectrophotometer.
What is specific rotation of a molecule? Why specific rotation is very important for a bioactive molecule?
Write down the instrumentation of a polarimeter.
"The sensitivity and resolution of NMR spectrum depends on applied magnetic field"- explain.
What are the requirements of polarimetric measurement?
Khulna University
Session: 2017-18
Pharmaceutical Analysis-1
What is titration? Classify reactions involved in titrimetric analysis.
Define primary and secondary standard. What are the characteristics of a primary standard?
What are the conditions of titrimetric analysis?
Describe the titration curve for the neutralization of weak base by strong acid.
Write short notes on
i) mixed indicator and
ii) universal indicator
Define nonaqueous titration. Classify solvents used in nonaqueous titration.
Define complexometric titration.
Write a short note on EDTA.
What are the applications of complexometric titrations?
Classify ligands used in complexometric titrations.
What is redox titration? Describe the titration curve for the titration of iron (II) with standard cerium (IV), monitored potentiometrically with platinum and calomel electrodes.
What does redox indicator mean? How does it help in the end point determination?
Justify the use of Potassium dichromate in redox titrations.
What is the correlation of wavelength, frequency and electromagnetic radiation?
What is the importance of chromophore and auxochrome to determine max of a compound in UV-visible spectroscopy?
Some absorbance spectrophotometers use double monochromators - Explain the reasons.
How do you perform quantitative assay of ampicillin in pharmaceutical formulation using UV-Vis spectroscopy?
What is stray light for an UV-spectrophotometer?
What is the fundamental difference between UV, IR and NMR in molecular level?
The absorbance co-efficient of a glycogen-iodine complex is 0.20 at light of 450 nm. What is the concentration when the transmission is 40% in a cuvette of 2 cm?
A conjugated diene absorbs at a higher wavelength with higher values of extinction co-efficient as compared to a non-conjugated diene- explain with suitable example.
Write down the structural formulas which are consistent with the observation indicated:
i) A ketone, C8 H14 O shows a UV maximum at 248 nm;
ii) An aldehyde, C8 H12 0 shows a UV maximum at 244 nm
What is Fieser-kuhn rule? Write down the lamda max of this molecule (Pic)
Briefly discuss the impact of chirality on a drug molecule.
What are the requirements of polarimetric measurement of a chiral molecule?
What is the specific rotation? Write short note on
i) Enantiomers ii) Diastereoisomers
Khulna University
Session: 2015-16
Pharmaceutical Analysis-1
What is the difference between strong acid and weak acid?
Describe the dissociation of water with necessary ionic equations.
Explain why NH3 is a base.
Mention the difference that you will see in the titration curve of a triprotic acid that of a monoprotic acid while titrating by a monobasic base.
"Selection of the right indicator for a given acid-base titration is important for the accurate determination of the endpoint"- explain.
Justify your answer which type of titrimetric method will you adopt for the assay of:
(i) weak acid soluble in water
(ii) weak base not soluble in water
(iii) heavy metals
A 50.0 ml sample of 0.50 M NaOH is titrated with 0.50 M HCI. What is the pH of the solution
(a) before adding any acid and (b) after adding 20.0 ml of NaOH?
Describe the usability of following indicators:
(i) Cresol red (transition range pH 0.2-1.8) (ii) Thymol blue (transition range pH 8.0-9.6)
Describe the basic principle of complexometric titration.
Define the following terms: (i) titration (ii) chelate
Can we do complexometric titration for anions? Justify your answer with example.
Why it is so important to adjust pH of reaction mixture in a complexometric titration?
Define non-aqueous titration. Which samples are suitable for non-aqueous titration?
Solvents can dictate the strength of an acid or base-explain this phenomenon in the light of non-aqueous titration.
Benzoic acid is a weak acid. How can you titrate it using non-aqueous titration method?
What is a redox titration? How can you determine the oxidation number of metals or nonmetals?
How do UV, IR. Mass and NMR spectroscopy helps in molecular structure determination? Briefly explain.
"A conjugated diene absorbs at a higher wavelength with higher values of extinction coefficient as compared to a diene in which double bonds are isolated"- Explain with example giving the chemistry involved.
The absorption coefficient of a glycogen-iodine complex is 0.20 at light of 450 nm. What is the concentration when the transmission is 40% in a cuvette of 2 cm?
UV spectroscopy is based on the principle of electronic transition- explain.
Some absorbance spectrometers use double monochromators, explain typical reasons.
Why do you need instrument calibration for analytical instrument? Briefly explain in the case of UV spectroscopy instrument.
What would you expect the spectrum of procaine to change the solvent from HCI to NaOH? Explain your answer.
Which of the following molecules would you expect absorb at a longer wavelength in the UV region of the electromagnetic spectrum? Explain your answer. (Pic)
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