Pharmaceutical Analysis-1 available questions for Islamic University: [IU-2020, IU-2019]
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[IU-2020] Pharmaceutical Analysis-1
Define sampling, population, accuracy and precession of sample analysis.
Mention analytical methods including quality control and assurance.
Why is sample preparation required in sample analysis?
What are some applications of statistics and data sciences in pharmaceutical analysis?
What are mean, variance and standard deviation for the following measurement of the same sample?
Define the following terms with respect to solution concentration:
i) Normality
ii) Molarity
iii) Formality
iv) Molality
v) Mole fraction
Discuss about different primary and secondary standard substances for titrimetric analysis.
How will you select an indicator in acids and bases titration?
Define acids and bases according to the Bronsted-Lowry theory? How do you determine the strength of Bronsted-Lowry a acid?
Arrange the Bronsted-Lowry acids according to their strength (ascending order):
H2O, H3O+, H2S, HI, CH3COOH, H3PO4
Calculate the pH of aqueous solution of 0.01 M HCI and 0.005M H₂SO4.
What is the acid-base indicator? State with reasons, what indicators you will chose for the following titration?
1) Na2CO3 vs HCl
2) NaOH vs CH3COOH
3) NaOH vs H₂SO4
Define with example:
(1) oxidant
(2) reduetant
How will you prepare 0.1N, 0.5N and 5N 250ml solution of Na2S2O; and Na2C2O4?
How is oxidation number assigned?
Complete and balance the following equations by ion-electron method:
i) K2Cr2O7+ KI+H₂SO4 →→→
ii) KMnO4 + H2SO4 + HCI →→→
Define the term masking agent with suitable example.
Explain the principle of complexometric titration. What are the advantages of it over other ordinary titration?
Balance the following redox reactions by ion-electron method:
Fe2+ + MnO4- + H+ = Mn2+ + Fe3+ + H₂O
Oxidation-reduction reactions occur simultaneously- Justify with example.
What do you mean Karl Fischer Titration (KFT)? Mention the applications of KFT.
Difference between Karl Fischer Titration and Bunsen Titration methods.
Give a preparation method of Karl Fischer reagent.
Discuss with a neat diagram of working principle of Karl Fischer volumetric moisture meter.
Explain why methanol is used as solvent instead of C2H5OH in KF Titration?
What do you mean by the tube dilution? Mention the principles of tube dilution.
Differentiate between MBC and MIC.
Discuss the potency determination of an antibiotic.
What does an assayer do? Write the characteristics of a good assay method.
Write short notes on:
Zone of inhibition
Agar diffusion method
important of pharmaceutical analysis
Advantages and disadvantages of bioassay determination of vitamins
Disk diffusion method for bioassay of antibiotics and vitamins
[IU-2019] Pharmaceutical Analysis-1
Define the term sampling, population, accuracy and precession in pharmaceutical data analysis.
Differentiate between quantitative analysis and qualitative analysis in pharmaceutical quality control.
Sort out and explain the following compounds as primary and secondary standard substances for there titrimetric analysis:
a) H2SO4 b) Na2C2O4 c) Na2CO3 d) NaOH
Define titrand and titrant.
What is an indicator? Write the application of indicators.
Write the equation of Karl Fischer titration reaction.
Why excess of Kl is used in iodometric titration?
Draw an apparatus of Coulometric-moisture meter.
What are the different concepts of acids and bases? Describe in brief.
Derive a theory for the color change pH range of an indicator in aqueous medium acid-bases titrations?
Write the structural formula with their ion formation of acid and base indicators (at least three of each).
Draw and compare the different acid-base titration curves (pH curves) for equivalence point determination.
What are basic principles and concepts of redox tritration?
Differentiate between indometric and iodimetric titration.
What the role of KMnO4, K2Cr2O7, Na2S2O3, KI, H2O2 and KBr in redox-titrations.
Flow do you prepare stoichiometrically of 0.1N, 250 ml of KMnO4 and K2Cr2O7 solution?
Balance the following redox equation:
Na2S2O3 + I2 -------
FeSO4 + K2Cr2O7 + HCl ------
Starch solution is never added in the beginning of the iodometric titration- explain.
What do you mean by sell indicator in redox titration?
Differentiate between temporary and permanent hardness of water.
Give some example of complexes, complex ion and chelating agents with their structural formula.
Discuss the procedure for the determination of Ca2+ and Mg2+ ions in a given solution and estimate the total hardness of water.
Discuss general procedure to determine moisture in a sample. Determine the loss on drying weight of sodium chloride.
What is Karl Fischer reagent? Describe the method of Karl Fischer reagent preparation.
Draw a Karl Fischer diagram and describe its working principle.
Went than by bioassay? Mention the advantage and limitation of bioassay.
Dillerentiate between quantal assay and graded assay.
Discuss the method of bioassay of vitamin.
Write the dice diffusion and turbidimetric method's principle.
Write short notes on:
Hardness of water
Assays
Standard deviations
What are electrolytes?
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